The Unwholesome actions produce a karmic seed that will definitely fruit.
For example, even if you killed someone out of self-defense, there would be a negative result.
Even if you got angry towards someone because they are harming themselves, you would produce a negative karmic seed.
That is why these are "unwholesome" fundamentally.
Many things that produce an un-sober state on the other hand only do so after a certain point. There are many medical situations where it is necessary. Many medicines have alcohol as an agent. The same goes for other inebriating drugs. It is of course better to avoid them altogether but there is no diet that is fundamentally unwholesome.
On the other hand, the unwholesome actions are on some fundamental level going to cause some karmic repercussion.